BactPac™: Empowering Progress with Delivery Innovation
Innovation in Cargo Capabilities
shRNA delivery by BactPac for siRNA-mediated RNA interference
Built using the BactPac delivery system, SiVEC-IAV is an siRNA-mediated therapeutic that inhibits influenza virus replication via the RNAi pathway.
mRNA delivery by BactPac
BactPac can express linear and circular eukaryote translatable mRNA (mRNAET), which can be translated into functional proteins after intracellular delivery to target cells.
Delivery of CRISPR/Cas gene editing systems by BactPac
BactPac can deliver pre-formed functional ribonucleoproteins (RNPs) comprising a nuclease and single guide RNA (sgRNA) for in vitro and in vivo gene editing applications.
Protein delivery by BactPac
BactPac can express and deliver a range of proteins, including single-domain antibodies. Delivery of proteins by BactPac enables the modification of intracellular pathways.
Innovation in Targeting
Ligand-mediated targeting
BactPac can reach a variety of organs and tissues, some of which are traditionally considered difficult to target.
Multiple administration routes
BactPac can be administered directly to the target tissue or can be administered systemically for broader distribution.
Useful for repeat dosing
Patients do not have pre-existing antibodies to BactPac, and repeat dosing does not induce a neutralizing antibody response.
Innovation in Safety
Favorable immune profile
BactPac has been engineered to reduce sensing by the immune system, reducing the possibility of adverse effects.
Rapid clearance
BactPac is cleared rapidly following administration and does not alter the target cell genome.
Favorable clearance routes
BactPac is not cleared by the liver, eliminating the risk for hepatotoxicity.
No proliferation
BactPac cannot proliferate outside of the laboratory - in the patient or the environment.
Innovation in Manufacturing
A vertically integrated system
BactPac produces its cargo during manufacturing, eliminating the need for expensive synthesis and packaging.
Production via standardized processes
BactPac is produced using standard bacterial fermentation processed that have been used in industry for decades.