Reach the right cells
Delivery begins with access to the intended tissue and interaction with the relevant cell population.
Next-generation therapies delivered by bacteria
Revolutionizing biologic delivery and making the undruggable druggable
SiVEC has developed BactPac, an engineered bacterial platform designed to produce and deliver therapeutic payloads inside selected cells.
Explore BactPacThe delivery challenge
A potent therapeutic cannot act on a target it never reaches.
Many therapeutic targets are located inside cells. Reaching those targets requires more than a potent payload. It requires a delivery system capable of reaching the relevant tissue, entering selected cells, and making functional cargo available in the correct intracellular location.
Cross the membrane
Many nucleic acids, proteins, antibodies, and gene-editing systems do not enter cells independently.
Release active cargo
Payloads must remain functional, reach the correct intracellular location, and persist long enough to produce a biological effect.
BactPac coordinates target-cell engagement, cellular entry, cargo production, and intracellular release within one engineered system.
BactPac
One platform. One integrated system.
- BactPac
- Produces and delivers therapeutic cargo.
- Payload
- Provides the therapeutic function.
Each SiVEC program pairs a defined BactPac configuration with a specific therapeutic payload.
How BactPac works
Target. Enter. Release.
Target
Engineered features support engagement with selected cells.
Enter
BactPac enters the target cell.
Release
BactPac lyses and releases the therapeutic payload.
Preclinical evidence
Evidence across the platform.
BactPac has demonstrated the versatility to produce and deliver diverse therapeutic payloads inside target cells and drive meaningful biological activity.
Multiple payload classes
BactPac can be engineered to produce and deliver RNA, protein, antibody, and gene-editing payloads, enabling multiple therapeutic modalities on a single platform.
Functional intracellular delivery
BactPac delivers biologically active therapeutic cargo inside target cells, enabling direct engagement of intracellular targets.
Program-level activity
Lead programs have generated robust preclinical activity across oncology and respiratory disease models.
Partner
Build what others can’t deliver.
Partner with SiVEC to transform biologic payloads into targeted therapeutics capable of acting inside target cells.
Partner with SiVEC